A systematic review on diverse synthetic route and pharmacological activities of benzimidazole as optimized lead

The aim of this review is to provide the systematic information synthetic scheme and biological activity synthesized benzimidazole derivatives. Benzimidazole widely used lead molecule for synthesis various types pharmacologically active moiety. It heterocyclic aromatic fused colorless solid having molecular mass 118.053 g/mol. basic in nature can be served as ligand coordination chemistry. bioactive compound showed pharmacological till now viz. anthelmintics (albendazole, mebendazole), proton pump inhibitors (omeprazole, pantoprazole), antibiotics, antiprotozoal, antifungal, anticancer, anti-viral, anti-oxidant, anti-inflammatory etc. Various route by methods also already reported. Some them are traditional convenient method, microwave reactor solvent free green method. Due its wide variety action similarity with biomolecule, it frequently taken new drug discovery